NCT02713581

IgG Dependent Monocyte Activation in Proximal Venous Thromboembolism

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 34 (actual)
• Sponsor: Centre Hospitalier Universitaire de Nīmes · Academic / Other
• Sex: Female
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The primary objective of this study is to search for, in vitro, elements associated with IgG-dependent monocyte activation (signaling pathway activation, expression of pro-coagulant and pro-inflammatory factors) and to describe their prevalence in female patients with a history of proximal venous thromboembolism (proximal deep vein thrombosis or pulmonary embolism) compared to control women.

Detailed description

The secondary objectives of this study include to compare the IgG-dependent monocyte activation profiles as a function of laboratory thrombophilia parameters. Essentially: Is IgG-dependent cell activation associated with the presence of anti-phospholipid antibodies (or their subtypes?), or do these profiles indicate something beyond the nosology of anti-phospholipid syndrome?

Conditions

• Venous Thromboembolism
• Pulmonary Embolism

Interventions

Type	Name	Description
BIOLOGICAL	Blood sampling	Venous blood will be sampled for laboratory analyses (see outcomes).

Timeline

• Start date: 2017-01-03
• Primary completion: 2019-01-03
• Completion: 2020-06-23
• First posted: 2016-03-18
• Last updated: 2020-06-30

Locations

2 sites across 1 country: France