NCT02711917

Rocuronium Consumption in Etomidate-based and Propofol-based General Anesthesia Under Sevoflurane

Consumption of Rocuronium Under Etomidate-based Versus Propofol-based Maintenance of General Anesthesia Under Different Concentration of Sevoflurane- BIS Guided Clinical Trial in a Closed Loop Infusion System

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 175 (actual)
• Sponsor: Tianjin Medical University General Hospital · Academic / Other
• Sex: All
• Age: 40 Years
• Healthy volunteers: Accepted

Summary

Different concentration of sevoflurane was given to maintain anesthesia. The dose of propofol to maintain BIS between 40-60 and the consumption of rocuronium was recorded and evaluated.

Detailed description

2 age group of patients was selected, 40-60 years and above 60 years. Maintenance of anesthesia was carried out using different concentration of Sevoflurane, ie MAC 0.5, 0.75 and 1.0. Bis value was kept between 40-60 and the dose of propofol required was recorded. Rocuronium infusion given in a close loop infusion system for different group was tabulated. The results was then analysed.

Conditions

• Neuromuscular Monitoring

Interventions

Type	Name	Description
DRUG	MAC 0.5	0.5 MAC Sevoflurane
DRUG	MAC 0.75	0.75 MAC Sevoflurane
DRUG	MAC 1.0	1.0 MAC Sevoflurane
DRUG	Propofol	Propofol consumption
DRUG	Etomidate	Etomidate consumption
DRUG	Rocuronium	Consumption of Rocuronium

Timeline

• Start date: 2015-07-01
• Primary completion: 2015-12-01
• Completion: 2016-01-01
• First posted: 2016-03-17
• Last updated: 2016-03-17