NCT02711306

Effects of Konjac Glucomannan Noodle Intervention in Subjects With Metabolic Syndrome

Office of Human Research, Taipei Medical University

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 36 (actual)
• Sponsor: Taipei Medical University · Academic / Other
• Sex: All
• Age: 20 Years – 64 Years
• Healthy volunteers: Not accepted

Summary

Metabolic syndrome (MS) is a complex disease with a cluster of risk factors and clinical features, which includes central or abdominal obesity, atherogenic dyslipidemia, impaired glucose regulation, hyperinsulinemia, high blood pressure, and concomitance of pro-inflammatory cytokine and insulin resistance. Glucomannan (GM) is a water-soluble dietary fiber derived from the root of Amorphophallus konjac that can improve blood sugar, blood fat concentration, and weight management, and has other health benefits.The purposes of this study are going to investigate the effects of KGM noodle (KGN) as stable food to MS and diabetic patients.

Detailed description

The KGN diet was composed of well-cooked noodle with 2 g of KGM in a dosage of 200 g/piece twice daily to substitute the daily carbohydrate for 4 weeks, with a 2-week washout period between alternative diets. All 33 subjects received two servings of either GMNs or PNs (400 g) per day, which replaced the main carbohydrate in two daily meals for 4 weeks. After a 2-week washout period, the subjects received the other type of noodle for 4 weeks. The body weight, BMI, waist circumference, fasting blood glucose and lipid profile, as well as serum vitamin A, E, β-carotene and high sensitivity C-reactive protein (hs-CPR) were measured by HPCL.

Conditions

• Metabolic Syndrome

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Glucomannan noodle	The participants received two servings (400 g) of GMN every day to replace their daily carbohydrate intake for 4 weeks.
DIETARY_SUPPLEMENT	Placebo noodle	In the placebo noodle diet, the participants received the same amount of noodles without glucomannan for 4 weeks.

Timeline

• Start date: 2013-05-01
• Primary completion: 2014-01-01
• Completion: 2014-03-01
• First posted: 2016-03-17
• Last updated: 2019-10-29
• Results posted: 2019-10-29