NCT02710487

Sleep, Awake & Move - Part II

Awake & Move. Role of Nocturnal Sleep and Rapid Eye Movement Sleep at Morning Awakening on Sleep Benefit in Parkinson's Disease. An Interventional Cross-over Study.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Neurocenter of Southern Switzerland · Academic / Other
• Sex: All
• Age: 35 Years
• Healthy volunteers: Not accepted

Summary

Sleep benefit (SB) is a prominent spontaneous, apparently unpredictable, transitory improvement in motor function reported by around 50% of patients affected by Parkinson's Disease (PD) after sleep and before taking their first dose of dopaminergic medications. The aim of this study is to test the hypothesis that objective and/or subjective improvement of motor function might be due to a carry-over effect of Rapid Eye Movements (REM) sleep at awakening from this sleep phase.

Detailed description

The "Awake \& Move" study is the second part of the Sleep, Awake \& Move project. This study will be conducted in a subgroup of unselected, consecutive patients having completed the part I of the Sleep, Awake \& Move project (i.e. the "Sleep \& Move" study). The investigators plan to explore the carry-over effect of REM sleep on motor function in a subgroup of PD subjects p. In this interventional study the investigators expect to induce SB by awakening the subjects from nocturnal REM sleep in a sleep laboratory setting, but not from Non-Rapid Eye Movements (NREM) sleep (control intervention).

Conditions

• Idiopathic Parkinson's Disease

Interventions

Type	Name	Description
BEHAVIORAL	REMSA	Awakening from REM sleep during the last hour of the sleep period
BEHAVIORAL	NREMSA	Awakening from N2 (NREM) sleep during the last hour of the sleep period

Timeline

• Start date: 2016-03-03
• Primary completion: 2018-01-12
• Completion: 2018-07-27
• First posted: 2016-03-16
• Last updated: 2018-08-27

Locations

1 site across 1 country: Switzerland