NCT02709356

Medium Chain Triglycerides and Brain Metabolism in Alzheimer's Disease

Proof of Concepts: Can a Supplement Ketogenic Based MCT Oil Increases Cerebral Capture Ketones in People With Alzheimer's Disease?

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Université de Sherbrooke · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Accepted

Summary

Evaluate and compare the changes in brain ketone and glucose uptake after taking two different MCT oil emulsions (60-40 oil or C8 oil) for one month, in a group of people with Alzheimer's disease and a control group.

Detailed description

Based on a PET/MRI protocol, the aim of this study is to evaluate and compare the response to the dietary supplementation of two different MCT oils (60% C10 + 40% C8 or 100 % C8) in two groups, patients with Alzheimer's disease and healthy elderly people (N=10/group). After a baseline evaluation, participant will test one of the supplements during two successive periods of one month; each period of time ending with 18F-FDG and 11C-acetoacetate PET scans.

Conditions

• Alzheimer's Disease

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	1-month of 60-40 MCT oil	1-month supplementation of 30 g MCT oil (60% C10 + 40% C8)/day
DIETARY_SUPPLEMENT	1-month of C8 MCT oil	1-month supplementation of 30 g MCT oil (100% C8)/day (1-month of C8 MCT oïl)

Timeline

• Start date: 2015-10-01
• Primary completion: 2018-02-01
• Completion: 2018-02-01
• First posted: 2016-03-16
• Last updated: 2018-10-10

Locations

1 site across 1 country: Canada