NCT02708537

Effect of Plasma Rich in Growth Factors on Semen Quality

Effect of Plasma Rich in Growth Factors (PRGF) on Semen Quality

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 20 (actual)
• Sponsor: IVI Bilbao · Academic / Other
• Sex: Male
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The hypothesis is growing semen samples with plasma rich in growth factors (PRGF), because it could improve sperm motility in patients subsidiary TRA, ultimately improving pregnancy rates.

Detailed description

Platelet growth factors are a group of proteins involved in cellular communication modifying biological responses. Obtaining plasma rich in growth factors is already widespread and simple protocol technique that is being used in various areas of medicine with superb results. Described many of the growth factors present in the PRGF are related to sperm parameters, especially motility The described effects have been studied in mammalian and each growth factor individually. PRGF contains a pool of growth factors and therefore be interesting to analyze their effect on various sperm parameters. One of those parameters is very important for fertilization sperm motility, since the lack of it will prevent displacement by the cervix to meet the egg in the fallopian tube.

Conditions

• Vascular Endothelial Growth Factor Overexpression

Interventions

Type	Name	Description
BIOLOGICAL	PRGF in candidates for sperm donors	PRGF application on seminal aliquots will be conducted at different concentrations assessing sperm motility.

Timeline

• Start date: 2016-04-01
• Primary completion: 2016-07-01
• Completion: 2017-12-01
• First posted: 2016-03-15
• Last updated: 2022-08-01

Locations

3 sites across 1 country: Spain