NCT02704065

Recurrent AA Amyloidosis After Renal Transplantation

Recurrent AA Amyloidosis After Renal Transplantation: Effects on Allograft Survival

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 54 (actual)
• Sponsor: Istanbul University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

End-stage renal disease related to AA amyloidosis is well characterized but there is limited data concerning patient and graft outcomes after renal transplantation. The aim of this study is to evaluate the clinical features of, and risk factors for recurrent AA amyloidosis, as well as the effects of these factors on the ultimate outcome of renal allografts.

Detailed description

AA amyloidosis is a rare but serious complication of several chronic inflammatory diseases including recurrent hereditary periodic fever syndromes. Although end-stage renal disease related to AA amyloidosis is well characterized, there is limited data concerning patient and graft outcomes after renal transplantation, with most of the findings reported from small series. Recurrence of amyloidosis in the renal allograft might be underdiagnosed, assessing graft and patient outcomes in larger study groups will bring better understanding and new strategies in daily practice.

Conditions

• AA Amyloidosis

Timeline

• Start date: 2016-02-01
• Primary completion: 2016-10-01
• Completion: 2016-12-01
• First posted: 2016-03-09
• Last updated: 2017-04-18

Locations

4 sites across 1 country: Turkey (Türkiye)