NCT02702245

Effects of Two Doses of Thylakoids on OGTT

Thylakoids' Effect on Glucose Homeostasis and Appetite Regulation After an Oral Glucose Tolerance Test in Healthy Volunteers

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 21 (actual)
• Sponsor: Region Skane · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

This cross-over intervention study aims to investigate the effect of two doses of thylakoids to an oral glucose tolerance test (OGTT) on glucose and insulin homeostasis as well as appetite regulating hormones in healthy volunteers.

Detailed description

A minimum of twenty healthy volunteers are recruited to participate in an OGTT at three different occasions separated by one week. At two of the occasions a green leaf extract, thylakoids, is added to a glucose solution; 5 gram or 10 gram in randomized order. The third occasion, without added thylakoids, serve as control. Blood samples are taken fasting and 15, 30, 45, 60, 90, 120 and 180 minutes after the glucose load. Blood samples are analysed for p-glucose, p-insulin, p-C-peptide, p-ghrelin, p-CCK and p-GLP-1.

Conditions

• Glucose Intolerance

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Experimental: Thylakoids 5 g	75 g pure glucose + 5 g chloroplast membranes from spinach leaves in a dried powder.
DIETARY_SUPPLEMENT	Experimental: Thylakoids 10 g	75 g pure glucose + 10 g chloroplast membranes from spinach leaves in a dried powder.
OTHER	Placebo Comparator: Control	75 g pure glucose.

Timeline

• Start date: 2014-01-01
• Primary completion: 2016-03-01
• Completion: 2017-03-01
• First posted: 2016-03-08
• Last updated: 2017-05-15