NCT02698878

Unloading Induced Effects on Local Glucose Uptake Into m. Soleus

Effects of Nutrition and Neuromuscular Electrical Stimulation on Local Glucose Uptake Into m. Soleus During 60 Days of Lower Leg Unloading

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 13 (actual)
• Sponsor: DLR German Aerospace Center · Academic / Other
• Sex: Male
• Age: 20 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The present study aimed to investigate whether a daily intake of lupin protein and a neuromuscular electrical stimulation training twice a day can improve local glucose uptake into m. soleus during a 60 day unloading phase with a special unloading device, the HEPHAISTOS orthosis (HEP).

Detailed description

The 60 day unloading intervention with the HEPHAISTOS unloading device had the following key objectives: primary hypothesis: * Assesment and evaluation of insulin sensitivity and local glucose uptake in the unloaded m. soleus and whether it can be improved by dietary supplementation of lupin seeds and neuromuscular electrical stimulation. secondary hypotheses: * Assesment and evaluation of unloading-induced reductions in muscle mass and whether they can be mitigated by dietary supplementation of lupin seed and neuromuscular electrical stimulation. * Assesment and evaluation of whole-body glycemic effects of the interventions.

Conditions

• Local Glucose Uptake
• Glucose Metabolism Disorders

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	lupin protein	19g of lupin crunchy every day for the whole duration of the intervention phase (60 days)
OTHER	Neuromuscular electrical stimulation	Individual neuromuscular electrical stimulation training had to be performed twice a day (morning and evening) over the whole duration of the intervention phase (60 days). Subjects were asked to continuously increase the intensity until a maximum intensity of 100mA per training.
DEVICE	HEPHAISTOS unloading orthotic device	Orthotic device which unloads the muscles of the lower leg. Subjects had to wear the device for the whole duration of the intervention phase (60 days).

Timeline

• Start date: 2014-04-01
• Primary completion: 2014-08-01
• Completion: 2014-08-01
• First posted: 2016-03-04
• Last updated: 2016-03-08