NCT02691416

Role of Propofol Postconditioning on Oxidative Stress and Cognitive Function

Role of Propofol Postconditioning on Oxidative Stress and Cognitive Function in Patients Undergoing Intracranial Aneurysm Surgery.

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: The Third Central Clinical College of Tianjin Medical University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The purpose of this study was to evaluate differences between propofol postconditioning and sevoflurane anesthesia in the intracranial aneurysm surgery about antioxidant effect.

Detailed description

intracranial aneurysm surgery may lead to regional ischemic reperfusion injury. Propofol, as an antioxidative phenol, has been demonstrated that mitigate the brain I/R in rats. As for sevoflurane, some investigation indicated that sevoflurane is able to reduce oxidative stress in cell(except neuronal cell lines ) and rodent models, but the antioxidant effect did not found in human minor incision surgeries, furthermore, oxidative stress was raised in the major surgeries including orthopedic surgeries, hysterectomy, cholecystectomy, and thoracotomy

Conditions

• Cerebral Arterial Aneurysm

Interventions

Type	Name	Description
DRUG	propofol postconditioning	administrated Target Controlled Infusion(TCI) of propofol (Cp 1.2ug/ml) and decreased sevoflurane with a Bispectral index (BIS) value of 40-60 to maintain anesthesia after clamp removal
DRUG	sevoflurane	0.5%-2% sevoflurane with BIS 40-60

Timeline

• Start date: 2014-07-01
• Primary completion: 2015-12-01
• Completion: 2016-01-01
• First posted: 2016-02-25
• Last updated: 2017-07-11
• Results posted: 2016-09-02