NCT02690532

Gut Permeability Assessment in Celiac and Gluten Sensitive Children

The Role of Gut Permeability in Developing Celiac Disease and Non-Celiac Gluten Sensitivity

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 40 (actual)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 2 Years – 17 Years
• Healthy volunteers: Accepted

Summary

This study will assess the effect of gluten on gut barrier function. Investigators at the Mayo Clinic have developed a new gut permeability test using rhamnose (sugar \& water solution), and are hoping to prove its effectiveness in a clinical setting.

Detailed description

The aim of this study is to assess effect of gluten on the gut barrier function in patients at high risk for celiac disease and non-celiac gluten sensitivity (NCGS) patients. This study will assess the gut permeability in three groups of patients 1) children who are at high risk for developing celiac disease (CD) (siblings of patients with celiac disease), 2) Children who are self-diagnosed with NCGS and 3) control group of patients matched for age and gender. Patients will undergo celiac serologic and genetic testing, after which the rhamnose test will be performed to assess the presence of increased gut permeability.

Conditions

• Celiac Disease

Timeline

• Start date: 2016-03-01
• Primary completion: 2018-07-01
• Completion: 2018-08-01
• First posted: 2016-02-24
• Last updated: 2018-08-15

Locations

1 site across 1 country: United States