NCT02688036

Hypofractionated vs. Conventionally Fractionated Concurrent CRT for LD-SCLC

Phase III Randomized Study of Hypofractionated vs Conventionally Fractionated Concurrent Chemo-radiotherapy for Limited Disease Small Cell Lung Cancer

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 860 (estimated)
• Sponsor: Chinese Academy of Medical Sciences · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether hypofractionated concurrent chemo-radiotherapy has the same efficiency as conventionally fractionated concurrent chemo-radiotherapy in Limited Disease Small Cell Lung Cancer.

Detailed description

For patients with Limited Disease Small Cell Lung Cancer, 45Gy/15F of radiotherapy with concurrent chemotherapy will be used in experimental arm. While 60Gy/30F of radiotherapy with concurrent chemotherapy will be used in the control arm. Both survival and toxicity of the two arms will be observed and compared.

Conditions

• Carcinoma, Small Cell
• Lung Neoplasms

Interventions

Type	Name	Description
RADIATION	hypofractionated concurrent chemoradiotherapy	For patients with Limited Disease Small Cell Lung Cancer, 45Gy/15F of radiotherapy with concurrent chemotherapy will be used in experimental arm.
RADIATION	conventionally fractionated concurrent chemoradiotherapy	For patients with Limited Disease Small Cell Lung Cancer, 60Gy/30F of radiotherapy with concurrent chemotherapy will be used in the control arm.

Timeline

• Start date: 2016-02-01
• Primary completion: 2019-12-01
• Completion: 2020-05-01
• First posted: 2016-02-23
• Last updated: 2018-01-02

Locations

1 site across 1 country: China