NCT02687347

Efficacy and Safety of Ultra-low Dose Methadone as Adjuvant Analgesic in Cancer Patients With Pain

A Double Blind Randomized Clinical Trial to Investigate the Efficacy and Safety of Ultra-low Dose Methadone as Adjuvant Analgesic Therapy in Cancer Patients With Pain

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 204 (estimated)
• Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The research hypothesis of this study is: In patients with moderate to severe cancer related pain, the addition of low dose methadone to an existing opioid significantly reduces pain severity compared to low doses morphine.

Conditions

• Pain, Intractable

Interventions

Type	Name	Description
DRUG	oral methadone	Oral methadone is the study drug
DRUG	oral morphine	Oral morphine is the active comparator. It is not a placebo intervention

Timeline

• Start date: 2016-02-01
• Primary completion: 2018-02-01
• Completion: 2018-12-01
• First posted: 2016-02-22
• Last updated: 2016-09-20

Locations

1 site across 1 country: Canada