Trials / Completed
CompletedNCT02684240
A 14 Day Early Bactericidal Activity Study of Nitazoxanide for the Treatment of Tuberculosis
- Status
- Completed
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- 30 (actual)
- Sponsor
- Weill Medical College of Cornell University · Academic / Other
- Sex
- All
- Age
- 18 Years – 65 Years
- Healthy volunteers
- Not accepted
Summary
This research is being done to determine if Nitazoxanide (NTZ) will cause a significant decrease in the number of M. tuberculosis bacteria in sputum after 14 days of treatment. The study is being conducted at the GHESKIO Centers in Port au Prince Haiti
Detailed description
This is a prospective randomized two-arm 14-day, early bactericidal activity study in treatment-naive, drug-susceptible patients with uncomplicated pulmonary tuberculosis (TB). The study will be conducted at the GHESKIO Centers in Port au Prince Haiti. Twenty patients will be randomized to receive NTZ 1 gram orally twice daily for 14 days. Ten patients will be randomized as positive controls to receive standard 4 drug tuberculosis therapy with isoniazid (H), rifampin (R), ethambutol (E), and pyrazinamide (PZA). Patients' sputum will be collected before and then every two days during 14 days of treatment, and the primary endpoint will be the change in the number of M. tuberculosis in patients' sputum. Our primary hypothesis is that NTZ will result in a significant decrease in the number of M. tuberculosis in sputum during14 days of treatment. The number of M. tuberculosis will be quantified by the time to positive (TTP) signal in hours in an automated liquid media culture system (BACTEC MGIT 960, Becton Dickinson).
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Nitazoxanide | nitazoxanide 1000 mg orally twice daily with food for 14 days |
| OTHER | Control | The control arm will receive WHO standard therapy for tuberculosis with isoniazid, rifampin, pyrazinamide, and ethambutol |
Timeline
- Start date
- 2016-02-01
- Primary completion
- 2018-04-11
- Completion
- 2018-04-11
- First posted
- 2016-02-17
- Last updated
- 2020-08-05
Locations
1 site across 1 country: Haiti
Source: ClinicalTrials.gov record NCT02684240. Inclusion in this directory is not an endorsement.