NCT02682732

Molecular Imaging to Capture Disease Heterogeneity in Acute Myeloid Leukemia

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (estimated)
• Sponsor: Hamilton Health Sciences Corporation · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The current understanding of acute myeloid leukemia (AML) is that one site of bone marrow (BM) sampling serves as a window that represents all AML cells distributed throughout the BM, an assumption that has yet to be questioned. Simulation in mice led to inconsistent representation of the full BM, which can incorrectly suggest the absence of leukemic cells. Positron-emission tomography (PET) scan can detect areas of high metabolic activity in the body using for instance a radioactive sugar. In one report, its use in human AML has provided proof-of-principle evidence of unequal distribution of AML cells in BM. Accordingly, the alternative hypothesis is to test if PET scan can demonstrate if BM geography can alter AML cells spread and home them as distinct areas rather than uniform spread as if they are distributed in liquid state.

Conditions

• Leukemia, Myeloid, Acute

Interventions

Type	Name	Description
PROCEDURE	FDG-PET/CT guided bone marrow sampling	(Fluorodeoxyglucose positron-emission tomography) FDG-PET/CT guided bone marrow sampling will be used to obtain two different samples from avid and dim bone marrow areas.

Timeline

• Start date: 2016-04-01
• Primary completion: 2019-12-01
• Completion: 2020-12-01
• First posted: 2016-02-15
• Last updated: 2018-02-22

Locations

1 site across 1 country: Canada