NCT02681627

Sim (Scratch in Miscarriage) Study

Pilot Randomised Controlled Trial of the Effect of Endometrial Scratch in Recurrent Miscarriage on Pregnancy Outcomes

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 109 (actual)
• Sponsor: University Hospitals Coventry and Warwickshire NHS Trust · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

There is increasing amount of evidence which suggests that miscarriage is related to a primary endometrial problem. Recent cochrane meta-analysis (March 2015) has proven that endometrial scratch improves live birth in women who underwent IVF. The aim of the study is to find out if scratch of the endometrium prevents recurrent miscarriage.

Detailed description

The Warwick BRU-RH (Biomedical Research Unit- Reproductive Health) hypothesis is that failed pregnancies are the result of failed decidualisation of the endometrium.

Conditions

• Recurrent Miscarriage

Interventions

Type	Name	Description
OTHER	Endometrial scratch	If patient randomised to intervention arm, will have speculum examination followed by endometrial scratch with a wallace catheter
OTHER	Touching the cervix	If patient is randomised to the control arm, she will have speculum examination followed by cleaning of the cervix with a cotton tip dipped in saline

Timeline

• Start date: 2015-11-30
• Primary completion: 2017-06-26
• Completion: 2017-09-01
• First posted: 2016-02-12
• Last updated: 2019-01-29

Locations

1 site across 1 country: United Kingdom