NCT02678728

Effect of Intraoperative Dexmedetomidine on Lung Protection Following Thoracic Aorta Surgery With Hypothermic Circulatory Arrest: a Randomized Clinical Trial

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 52 (estimated)
• Sponsor: Gangnam Severance Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 98 Years
• Healthy volunteers: Not accepted

Summary

Dexmedetomidine has been known to protect the lung against inflammation and oxidative stress in diverse clinical settings. The investigators aimed to investigate the lung protective effect of dexmedetomidine in patients undergoing thoracic aortic surgery with hypothermic circulatory arrest, which is associated with systemic inflammatory response, and oxidative stress.

Detailed description

Patients will be divided into 2 groups; dexmedetomidine group and control group. Dexmedetomidine group will receive dexmedetomidine during and after thoracic artery surgery. And control group will receive the same amount of normal saline instead. Analyzing patients lung function and serum factors, which indicates the degree of systemic inflammatory responses and oxidative stress, The investigators will investigate the protective effect of dexmedetomidine on lung.

Conditions

• Chronic Dissecting Aneurysm of Thoracic Aorta
• Chronic Nontraumatic Dissection of Thoracic Aorta
• Dissecting Aneurysm of the Thoracic Aorta

Interventions

Type	Name	Description
DRUG	Dexmedetomidine	1ug/kg IV loading over 20 minutes followed by 0.5ug/kg/hr IV infusion until 12 hrs of aortic cross clamp off
DRUG	normal saline	IV loading and infusion of same volume of normal saline after induction until 12 hrs of aortic cross clamp off

Timeline

• Start date: 2016-02-01
• Primary completion: 2018-02-28
• Completion: 2018-03-30
• First posted: 2016-02-10
• Last updated: 2019-08-14

Locations

1 site across 1 country: South Korea