NCT02677480

The Effect of Probiotic Streptococci and pH-rising Components on the Oral Microbial Flora

The Effect of Probiotic Streptococci and pH-rising Components on the Oral Microbial Flora in Subjects With Reduced Salivary Secretion Rate

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Göteborg University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The test group consisted of eighteen subjects with hyposalivation used probiotic tablets (≥ 4/day) and gel (once a week) (streptococci, bicarbonate and carbamide) for 3 months and 9 used placebo tablets and gel. The salivary secretion rates were measured and microbial samples collected and analysed using cultivation technique twice both at baseline and at the 3-month follow up (1-2 weeks between the appointments).

Detailed description

The aim was to analyse the effect of daily intake of probiotic alpha-haemolytic facultative anaerobic streptococci (Streptococcus oralis), pH-rising components and Stevia on the oral microflora in hyposalivated subjects. Material and methods: Subjects with hyposalivation (unstimulated secretion rate of \< 0.1 ml/min and/or a stimulated secretion rate \< 0.7 ml/min) and ≥ 10 000 cfu/ml of mutans streptococci and/or lactobacilli on the tongue or in the supragingival plaque were included. Eighteen subjects used probiotic tablets (≥ 4/day) and gel (once a week) for 3 months and 9 used placebo tablets and gel. The salivary secretion rates were measured and microbial samples collected and analysed using cultivation technique twice both at baseline and at the 3-month follow up (1-2 weeks between the appointments).

Conditions

• Hyposalivation

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Test group, probiotic tablets and gel	Effect of probiotic tablets and gel on acidogenic bacteria
DIETARY_SUPPLEMENT	Placebo group, placebo tablets and gel	Effect of placebo tablets and gel on acidogenic bacteria

Timeline

• Start date: 2010-11-01
• Primary completion: 2010-11-01
• Completion: 2010-11-01
• First posted: 2016-02-09
• Last updated: 2016-02-09

Locations

1 site across 1 country: Sweden