NCT02676011

Brad Arrhythmia Induced by Repeated Succinylcholine During Gynecological Laparoscopic Surgery

Prevention of Brad Arrhythmia Induced by Repeated Succinylcholine by Atropine Sulfate During Gynecological Laparoscopic Surgery: a Randomized Controlled Trial

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: Assiut University · Academic / Other
• Sex: Female
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

Cardiac arrhythmias are a well-recognized complication of anesthesia for laparoscopy. The aim of this study was to evaluate the efficacy of atropine sulfate for prevention of brad arrhythmia induced by repeated succinylcholine during gynecological laparoscopic surgery.

Detailed description

120 candidates, ASA 1 in the age range 18-40 years scheduled for elective diagnostic gynecological laparoscopic surgery were randomly assigned into 4 groups to receive either atropine sulfate or normal saline solution (as placebo).

Conditions

• Bradycardia

Interventions

Type	Name	Description
DRUG	IM atropine	Atropine (0.01 mg/kg) (1 ml) IM 30 minutes before induction of anesthesia
DRUG	IV atropine	Atropine (0.01 mg/kg) intravenously (10 ml) 3 minutes before induction of anesthesia
DRUG	Atropine mixed with second dose succinylcholine	Atropine (0.01 mg/kg) added to the second dose succinylcholine (1mg/kg) prepared to 5 ml syringe with normal saline
DRUG	IM normal saline	1 ml normal saline IM 30 minutes before induction of anesthesia
DRUG	IV normal saline	IV 10 ml normal saline 3 minutes before induction of anesthesia
DRUG	Normal saline mixed with second dose succinylcholine	Second dose succinylcholine (1 mg/kg) prepared to 5 ml syringe with normal saline

Timeline

• Start date: 2016-02-01
• Primary completion: 2016-05-01
• Completion: 2016-05-01
• First posted: 2016-02-05
• Last updated: 2016-09-27

Locations

1 site across 1 country: Egypt