NCT02675192

Biological Aging of Skeletal Muscles in Humans

Biological Aging of Skeletal Muscles in Humans, a Monocentric, Prospective Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 72 (actual)
• Sponsor: Centre Hospitalier Universitaire de Saint Etienne · Academic / Other
• Sex: All
• Age: 80 Years – 83 Years
• Healthy volunteers: Accepted

Summary

Aging affects almost all the tissues and physiological functions, and skeletal muscle is the most affected organ. The progressive decline of the weight and the muscular function linked to the aging contributes to the lack of autonomy and dependence, but also to an increase of the mortality risks. Sarcopenia is also a prevalent condition, because it is detected in 13-24% of 60 years old, and 50% of 80 years old and more. However, strong inter-individual variations of this prevalence of sarcopenia exists. The key issue is to understand why the biological aging of the skeletal muscle is so different between people. In this study, mechanisms involved in biological aging of the skeletal muscle in aging people (same chronological age) will be specified.

Detailed description

Aging affects almost all the tissues and physiological functions, and skeletal muscle is the most affected organ. The progressive decline of the weight and the muscular function linked to the aging contributes to the lack of autonomy and dependence, but also to an increase of the mortality risks. Sarcopenia is also a prevalent condition, because it is detected in 13-24% of 60 years old, and 50% of 80 years old and more. However, strong inter-individual variations of this prevalence of sarcopenia exists. Some elderly (60 years old) reveal a biological aging of 80 years old, whereas 60 years old people reveal a biological aging of 60 years old. The key issue is to understand why the biological aging of the skeletal muscle is so different between people. Previous sarcopenia studies in Humans did not really focus on chronological aging, they were all based on a comparison between young and old people. No study considered inter-individual modifications (biological aging) in sarcopenia. Furthermore, few studies were associated in the same study to "omic", histological, and epigenetic data, to obtain integrated point of view of Human Sarcopenia. In this study, mechanisms involved in biological aging of the skeletal muscle in aging people (same chronological age) will be specified.

Conditions

• HEALTHY

Interventions

Type	Name	Description
OTHER	Proof cohort : muscular assessment	Clinical examination, blood appraisal, urinary collection, MVC, checking muscle functional skills and muscular biopsy will be performed.

Timeline

• Start date: 2016-02-18
• Primary completion: 2017-01-20
• Completion: 2017-05-23
• First posted: 2016-02-05
• Last updated: 2021-11-17

Locations

1 site across 1 country: France