NCT02673229

Comparison of Collagenase With Antibiotic Ointment of Minor Partial Thickness Burns

Comparison of Collagenase Santyl Ointment With Antibiotic Ointment in the Outpatient Care of Minor Partial Thickness Burns

• Status: Terminated
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: University of Kansas Medical Center · Academic / Other
• Sex: All
• Age: 2 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

By doing this study, researchers hope to learn if applying Santyl to the burn during the healing process affects the appearance of the resulting scar.

Detailed description

Subjects who have minor, second degree burns may be enrolled in this study. Subjects will receive either Santyl ointment or bacitracin ointment to apply to the burn until it heals. Bandages will be used to keep the burn covered while it heals. Second degree burns generally leave a scar. Once the burn heals, lotion and an appropriate bandage will be used to try to minimize the appearance of a scar. The study hypothesis is that burns treated with Santyl will have a better scar appearance than burns treated with bacitracin. Subjects enrolled in this study will make once a week visits to the University of Kansas Medical Center outpatient burn clinic until the burn heals. The burn will be assessed for healing at these visits. Once healed, visits to the clinic will be at 60 \& 180 days, up to 6 months. At these visits, the appearance of the scar will be evaluated. This study was originally funded by Smith and Nephew, but Smith and Nephew is no longer providing support for the study.

Conditions

• Burn, Partial Thickness

Interventions

Type	Name	Description
DRUG	Collagenase Santyl	A sterile, enzymatic debriding agent which contains 250 collagenase units per gram of white petrolatum, United States Pharmacopeia (USP).
DRUG	Bacitracin	One gram is equal to 500 bacitracin units; one unit of bacitracin is equivalent to 0.026 milligrams.

Timeline

• Start date: 2013-09-30
• Primary completion: 2018-12-27
• Completion: 2020-03-30
• First posted: 2016-02-03
• Last updated: 2024-07-10
• Results posted: 2024-07-10

Locations

1 site across 1 country: United States