NCT02670382

Role of Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) on Inflammation and Lipids

Role of EPA and DHA in Fish Oil on Inflammation and Lipoprotein Metabolism

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Tufts University · Academic / Other
• Sex: All
• Age: 50 Years – 75 Years
• Healthy volunteers: Accepted

Summary

The objective of this study is to provide critical information regarding both common and distinctive roles of EPA and DHA in systemic inflammation and lipid metabolism.

Detailed description

This is a randomized, placebo-controlled, double-blind, crossover study of the effects of EPA and DHA on inflammation and lipid metabolism in 24 men and women with metabolic syndrome. The study will characterize the effects of EPA alone and DHA alone, relative to each other and to placebo, on plasma biomarkers of inflammation, inflammatory cell activation and gene expression, and plasma lipid and lipoprotein levels.

Conditions

• Metabolic Syndrome

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	EPA	10 week supplementation
DIETARY_SUPPLEMENT	DHA	10 week supplementation
DIETARY_SUPPLEMENT	sunflower oil	4-week lead-in

Timeline

• Start date: 2016-03-01
• Primary completion: 2020-05-01
• Completion: 2020-10-01
• First posted: 2016-02-01
• Last updated: 2021-04-14
• Results posted: 2021-04-14

Locations

1 site across 1 country: United States