NCT02669394

Reshaping the Path of Vascular Cognitive Impairment (VCI)

Reshaping the Path of Vascular Cognitive Impairment With Resistance Training

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 91 (actual)
• Sponsor: University of British Columbia · Academic / Other
• Sex: All
• Age: 55 Years
• Healthy volunteers: Not accepted

Summary

The investigators will conduct a proof-of-concept randomized controlled trial study to provide preliminary evidence of efficacy of a resistance exercise training program for maintaining white matter health and improving cognitive function in older adults with vascular cognitive impairment, defined as the presence of cognitive impairment combined with cerebral small vessel disease, compared with a stretch and relaxation program.

Detailed description

A total of 88 adults with vascular cognitive impairment will be randomized to either a 12-month twice-weekly resistance training program or stretch and relaxation program. There will be three measurement sessions: baseline, 6 months (midpoint of intervention period), and 12 months (end of intervention period).

Conditions

• Transient Ischemic Attack
• Vascular Cognitive Impairment
• Subcortical Vascular Dementia

Interventions

Type	Name	Description
BEHAVIORAL	Resistance exercise training	Twelve months of twice-weekly resistance training program that will gradually progress in intensity. Each training session will be 60 minutes (10 minutes of warm-up, 40 minutes of training, and 10 minutes of cool-down).
BEHAVIORAL	Control: stretching and relaxation program	Twelve months of twice-weekly stretching and relaxation program that includes stretches, deep breathing and relaxation techniques, general core control exercises, and general posture and health education. Each session will be 60 minutes.

Timeline

• Start date: 2016-05-17
• Primary completion: 2022-06-02
• Completion: 2022-06-02
• First posted: 2016-02-01
• Last updated: 2026-03-17

Locations

1 site across 1 country: Canada