NCT02666690

Study of the Intra-patient Variability of the Quantitative Parameters of Tumor Perfusion Evaluated With Ultrasound Contrast

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 59 (actual)
• Sponsor: Gustave Roussy, Cancer Campus, Grand Paris · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

RECIST criteria for evaluating tumor response are often inadequate for the evaluation of anti-angiogenic drugs. An evaluation model of tumor perfusion with contrast-enhanced ultrasonography was developed at Gustave Roussy. It assesses the tumor vascular response through the analysis of 7 different parameters. Several studies (four at IGR, involving 117 patients, and a multicenter study involving 400 patients) showed that CEUS allows early evaluation of the effect of anti-angiogenic drugs. Two of these parameters are particularly interesting for the early identification of patients responding (or not) to treatment. Those are area under curve , and area under the wash-out. To further validate the use of these parameters, it is essential to measure and describe the level of their intra-patient variability.

Conditions

• GIST Metastatic Cancer
• Breast Metastatic Cancer
• Kidney Metastatic Cancer
• Colon Metastatic Cancer
• Rectal Metastatic Cancer

Interventions

Type	Name	Description
DEVICE	CEUS (Contrast-enhanced ultrasound)	Each patient will be performed 2 contrast echocardiography (a pre-prandial - a post-prandial) before the antiangiogenic treatment, at D15 and D30.

Timeline

• Start date: 2011-07-01
• Primary completion: 2013-09-01
• Completion: 2013-10-01
• First posted: 2016-01-28
• Last updated: 2016-06-09

Locations

1 site across 1 country: France