NCT02665715

Can Postprandial Reactive Hypoglycaemia be Reduced in Patients After Roux-en-Y Gastric Bypass With a Low Carbohydrate Diet?

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Amirsalar Samkani · Academic / Other
• Sex: All
• Age: 25 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Roux-en-Y gastric bypass (RYGB) accelerates nutrient delivery to the small intestine causing higher peak blood glucose concentration early after meal intake. In the late postprandial period (1 1⁄2-2 h) nadir blood glucose level is lower compared with before operation. In some patients, overt postprandial hypoglycaemia develops, and is typically reported as a complication 1-5 years postoperatively, when maximal weight loss has been obtained. The pathophysiology of postprandial hypoglycaemia involves inappropriate hyper-secretion of insulin associated with exaggerated secretion of the gut hormone glucagon-like peptide-1 (GLP-1) leading to a mismatch between glucose absorption rate, insulin secretion and whole body glucose disposal. We hypothesize that lowering carbohydrate content of meals reduces postprandial glucose excursions whereby GLP-1 and insulin secretion is reduced and reactive hypoglycemia prevented.

Conditions

• Bariatric Surgery (Gastric Bypass)

Interventions

Type	Name	Description
OTHER	Low carbohydrate meals	Meal macronutritional energy composition: Carbohydrate 30% Protein 30% Fat 40%
OTHER	Standard carbohydrate meals	Meal macronutritional energy composition: Carbohydrate 55% Protein 15% Fat 30%

Timeline

• Start date: 2015-08-01
• Primary completion: 2016-06-01
• Completion: 2016-06-01
• First posted: 2016-01-28
• Last updated: 2016-07-21

Locations

1 site across 1 country: Denmark