NCT02661191

Vitamin D Deficiency and Asthma Exacerbation

Effect of Vitamin D Repletion on Asthma Exacerbation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 119 (actual)
• Sponsor: University of Turin, Italy · Academic / Other
• Sex: All
• Age: 12 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The study aim is in two phases. First phase: to evaluate the influence of vitamin D deficiency on asthma severity, degree of airway obstruction and frequency of asthma exacerbations. Second phase: to evaluate if in patients with vitamin D deficiency (25-OH vitamin D levels below 20 ng/ml), vitamin D supplementation decreases the number of disease exacerbations.

Detailed description

The first phase of the study consisted of a cross-sectional examination of a cohort of 119 asthmatic patients, who had at least one year regular follow-up in our respiratory clinic, and were not receiving any vitamin D supplementation. In the second phase patients with vitamin D deficiency (25-OH D values below 20 ng/ml), were recruited in a one year longitudinal study, during which they received vitamin D supplementation. The study started and ended in late autumn-winter season when, at our latitude, sun exposure is lowest. Symptoms, spirometry and number of exacerbations were recorded during both study phases.

Conditions

• Asthma
• Vitamin D Deficiency
• Disease Exacerbation

Interventions

Type	Name	Description
DRUG	oral cholecalciferol	Inhaled corticosteroids and long-acting beta-agonists, salbutamol

Timeline

• Start date: 2012-10-01
• Primary completion: 2013-03-01
• Completion: 2014-03-01
• First posted: 2016-01-22
• Last updated: 2016-01-22