NCT02659410

Impact of Thermal Stress on Pulmonary Absorption and Toxicokinetics of 3 Organic Solvents

Studying the Impact of Thermal Stress (Heat) Representative of Occupational Settings on Pulmonary Absorption and Toxicokinetics of 3 Organic Solvents

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 5 (estimated)
• Sponsor: Université de Montréal · Academic / Other
• Sex: Male
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

In Quebec, thousands of workers are concomitantly exposed to heat and chemical compounds. Exposure to heat induces physiological responses that help maintaining a stable body temperature. Those changes can affect organ functions implicated in absorption and metabolism. According to literature, those changes could lead to increased concentrations of chemical compounds in the body and their toxicity. Therefore, the aim of this study is to evaluate the pulmonary absorption and toxicokinetics of 3 organic solvents in heat stress conditions in volunteers exposed in a inhalation chamber. Results will then be used to develop PBPK models that will allow to predict organic solvent kinetics when coexposed with heat.

Conditions

• Heat

Interventions

Type	Name	Description
OTHER	Heat stress (21)	4h exposure to heat (WBGT of 21°C), no solvent
OTHER	Heat stress (25)	4h exposure to heat (WBGT of 25°C), no solvent
OTHER	Heat stress (30)	4h exposure to heat (WBGT of 30°C), no solvent
OTHER	Heat Stress (21) +TOL	4h exposure to heat (WBGT of 21°C) + Toluene (concentration = TLV)
OTHER	Heat stress (25) + TOL	4h exposure to heat (WBGT of 25°C) + Toluene (concentration = TLV)
OTHER	Heat stress (21) + TOL	4h exposure to heat (WBGT of 30°C) + Toluene (concentration = TLV)
OTHER	Heat stress (21) + ACE	4h exposure to heat (WBGT of 21°C) + Acetone (concentration = TLV)
OTHER	Heat stress (25) + ACE	4h exposure to heat (WBGT of 25°C) + Acetone (concentration = TLV)
OTHER	Heat stress (30) + ACE	4h exposure to heat (WBGT of 30°C) + Acetone (concentration = TLV)
OTHER	Heat stress (21) + DCM	4h exposure to heat (WBGT of 21°C) + Dichloromethane (concentration = TLV)
OTHER	Heat stress (25) + DCM	4h exposure to heat (WBGT of 25°C) + Dichloromethane (concentration = TLV)
OTHER	Heat stress (30) + DCM	4h exposure to heat (WBGT of 30°C) + Dichloromethane (concentration = TLV)
OTHER	Heat stress (21) + TOL (dermal)	4h exposure to heat (WBGT of 21°C) + Toluene (concentration = TLV), participants breath normal air through a mask for evaluation of dermal absorption.
OTHER	Heat stress (25) + TOL (dermal)	4h exposure to heat (WBGT of 25°C) + Toluene (concentration = TLV), participants breath normal air through a mask for evaluation of dermal absorption.
OTHER	Heat stress (30) + TOL (dermal)	4h exposure to heat (WBGT of 30°C) + Toluene (concentration = TLV), participants breath normal air through a mask for evaluation of dermal absorption.

Timeline

• Start date: 2015-11-01
• Primary completion: 2016-08-01
• Completion: 2018-06-01
• First posted: 2016-01-20
• Last updated: 2016-01-20

Locations

1 site across 1 country: Canada