NCT02656186

Supplementation With Nutrients Modulating IGF-1 and Cytokines in Elderly People at Risk of Undernutrition

Supplementation With Nutrients Modulating IGF-1 Negatively Correlated With Changes in the Levels of Proinflammatory Cytokines in Community-dwelling Elderly People at Risk of Undernutrition

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Yonsei University · Academic / Other
• Sex: All
• Age: 65 Years – 86 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study was to determine the improvement in nutritional status, especially in the level of insulin-like growth factor-1 (IGF-1) and its relationship with changes in the circulating cytokine levels, after providing extra protein and energy contents to community-dwelling older adults at risk of undernutrition.

Detailed description

Sixty of aged over 65 years, living independently in the community for elderly people, nondiabetic subjects with serum prealbumin of under 30 mg/dL and BMI under 25 kg/m2 were recruited. The subjects were followed for a 2-week pre-intervention period, followed by an intervention period, which they received 2 cartons of liquid oral nutritional supplementation daily for 2 weeks.

Conditions

• Undernutrition

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Pre-intervention	First 2-weeks : keeping routine dietary habit
DIETARY_SUPPLEMENT	Liquid nutritional supplement	Pre-intervention period was followed by an intervention period, during which consumed twice-daily 200 mL cartons of oral liquid nutritional supplementation (total 400 mL daily, containing 16 g protein, 12 g fat and 60 g carbohydrate and providing 400 kcal)

Timeline

• Start date: 2015-05-01
• Primary completion: 2015-12-01
• Completion: 2015-12-01
• First posted: 2016-01-14
• Last updated: 2016-01-18