NCT02655380

Remifentanil Requirement for Acceptable Intubating Condition

Remifentanil Requirement for Acceptable Intubating Condition With Two Dose Ketamine Without Neuromuscular Blocking Agent in Children

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 51 (actual)
• Sponsor: Ajou University School of Medicine · Academic / Other
• Sex: All
• Age: 3 Years – 12 Years
• Healthy volunteers: Not accepted

Summary

Ketamine and opioid are known to improve the intubating condition, respectively. Combination of ketamine and opioid potentiate analgesic effect and give hemodynamic stability in complementary manner. Therefore, the combination use of ketamine and remifentanil could be useful for acceptable intubating condition in the general anesthesia without the use of neuromuscular blocking agent. Generally, induction dose of ketamine ranges between 1 and 2 mg. There was no report about the optimal dose of remifentanil with 1 or 2 mg ketamine induction dose for intubation without neuromuscular blocking agent. The investigators focus on remifentanil dose using Dixon's up and down method.

Conditions

• Intubating Condition

Interventions

Type	Name	Description
DRUG	Ketamine 1	Anesthesia induction is performed with 1 mg ketamine.
DRUG	Ketamine 2	Anesthesia induction is performed with 2 mg ketamine.
DRUG	Remifentanil	After anesthesia induction with ketamine, predetermined remifentanil using Dixon's up and dowm method is administered.

Timeline

• Start date: 2017-06-19
• Primary completion: 2018-04-16
• Completion: 2018-04-16
• First posted: 2016-01-14
• Last updated: 2019-01-10

Locations

1 site across 1 country: South Korea