NCT02655302

Study of the Involvement of IL-17 / IL-22 Pathway in Bacterial Exacerbations of COPD

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: University Hospital, Lille · Academic / Other
• Sex: All
• Age: 40 Years
• Healthy volunteers: Not accepted

Summary

Chronic obstructive pulmonary disease (COPD) is a worldwide chronic inflammatory disease of the airways linked to environmental exposure. The chronic course of COPD is often interrupted by acute exacerbations which have a major impact on the morbidity and mortality of COPD patients. A bacterial etiology for these exacerbations is common (almost 50%). Moreover, airway bacterial colonization linked to an increased susceptibility is observed in COPD patients. Effective Th17 immune response is needed to develop a good response against bacteria. Thus, this study aims to demonstrate that there is a defective IL-17/ IL-22 response to bacteria in COPD leading to airway bacterial colonization and infection.

Conditions

• Pulmonary Disease, Chronic Obstructive
• Bacterial Infections

Interventions

Type	Name	Description
OTHER	Sample collecting	Collect sputum, blood and nasopharyngeal swab during the exacerbation and at steady state 8 to 16 weeks later.
OTHER	Lung function measure	Measure lung function and follow it during 4 years

Timeline

• Start date: 2018-07-04
• Primary completion: 2028-07-01
• Completion: 2028-07-01
• First posted: 2016-01-14
• Last updated: 2023-01-27

Locations

4 sites across 1 country: France