NCT02653469

Augmented Pulse Pressure Variation to Predict Fluid Responsiveness in Open Laparotomy

Pulse Pressure Variation With Augmented Ventilation to Predict Fluid Responsiveness in the Patients Undergoing Open Laparotomy Surgery

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 38 (actual)
• Sponsor: Samsung Medical Center · Academic / Other
• Sex: All
• Age: 20 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Pulse pressure variation (PPV) is a well-known and widely used dynamic preload indicator based on heart-lung interaction to predict fluid responsiveness. Generally, patients are considered to be fluid-responsive when the PPV value larger than 11-13%. However, several previous researches demonstrated that there is a zone of uncertainty (grey zone) in PPV. To predict fluid-responsiveness accurately in the patients with PPV within grey zone (9-13%), the investigators would evaluate the augmented PPV using augmented ventilation.

Conditions

• Gynecologic Neoplasms
• Abdominal Neoplasms

Interventions

Type	Name	Description
OTHER	Augmented ventilation	When the patient's PPV is within grey zone, patient's tidal volume is maintained with augmented tidal volume of 12 ml/kg (from normal ventilation of 8ml/kg) for 2min duration.
OTHER	Fluid loading	We record the stroke volume index (SVI) values before and after volume expansion with 6ml/kg of balanced crystalloid

Timeline

• Start date: 2015-09-01
• Primary completion: 2016-02-01
• Completion: 2016-02-01
• First posted: 2016-01-12
• Last updated: 2016-03-04

Locations

1 site across 1 country: South Korea