NCT02652507

Dexmedetomidine and Ketamine in MRI

Effect of a Combination of Dexmedetomidine and Ketamine Anesthesia on Upper Airway Morphology in Children

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 22 (estimated)
• Sponsor: Children's Hospital Medical Center, Cincinnati · Academic / Other
• Sex: All
• Age: 1 Year – 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this research study is to examine the effects of two commonly used anesthetic drugs, dexmedetomidine and ketamine, have on the shape and muscle tone of the upper airway in children, adolescents, and young adults. The results of this study will help in making the best decisions regarding the anesthesia medications used for sedation outside of the operating room.

Detailed description

Upper airway obstruction is a common problem in spontaneously breathing patients under anesthesia. This study is examining the effects of combining dexmedetomidine and ketamine on the muscle tone and airway configuration in children under anesthesia. The hypothesis is adding ketamine to dexmedetomidine will not significantly reduce airway caliber or morphology when compared to previously collected data using dexmedetomidine alone.

Conditions

• Magnetic Resonance Imaging

Interventions

Type	Name	Description
DRUG	Dexmedetomidine	2 mc/kg/h over ten minutes followed by a continuous infusion of 2 mcg/kg/h
DRUG	Ketamine	Bolus dose 2 mg/kg after first set of research images are obtained

Timeline

• Start date: 2016-06-01
• Primary completion: 2018-05-01
• Completion: 2018-05-01
• First posted: 2016-01-12
• Last updated: 2019-07-24

Locations

1 site across 1 country: United States