NCT02652247

Serial, Non-invasive Analysis of Exhaled Breath Condensate in Ventilated Trauma Patients

Serial, Non-invasive Molecular Analysis of Exhaled Breath Condensate to Define the Pulmonary Flora in Critically Injured, Ventilated Adults: The Clinical Trial

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 110 (actual)
• Sponsor: Vanderbilt University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

To determine if the analysis of exhaled breath condensate correlates with the development \& resolution of pneumonia.

Detailed description

This proposal investigates the utility of exhaled breath condensate fluid (EBCF) collected from heat moisture exchange (HME) filters connected to patient's endotracheal tubes for early, non-invasive detection of ventilator-associated pneumonia (VAP) in critically ill or injured ICU patients. The development of pneumonia during mechanical ventilation is the most common healthcare-associated infection in severely injured patients, accounting for substantial morbidity, excess ICU and hospital stay, additional cost and increased mortality.

Conditions

• Ventilator Associated Pneumonia (VAP)

Interventions

Type	Name	Description
PROCEDURE	molecular analysis of exhaled breath condensate
PROCEDURE	molecular analysis of mini-bronchoalveolar lavage (BAL) aspirate
PROCEDURE	molecular analysis of bronchoalveolar lavage (BAL) aspirate

Timeline

• Start date: 2016-01-01
• Primary completion: 2022-06-01
• Completion: 2022-06-01
• First posted: 2016-01-11
• Last updated: 2022-08-04

Locations

1 site across 1 country: United States