NCT02650947

Sucralose Effects on Glucose Metabolism and Gut Microbiota

Effects of Sucralose Consumption on Glucose Metabolism, Incretin and Gut Microbiota in Healthy Adult

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: Ramathibodi Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Hypothesis: 1. Long-term consumption of sucralose may effect glucose metabolism, incretin hormone secretion and gut microbiota in healthy adults. 2. Long-term consumption of sucralose may alter food behaviour in healthy adults.

Detailed description

Artificial sweeteners such as sucralose, are among the most widely used food additives worldwide. Artificial sweetener consumption is considered safe and beneficial owing to their low caloric content. However, many emerging evidences showed artificial sweeteners may induce glucose intolerance. The objectives of this study were to determine the effect of sucralose on glycemic response, insulin secretion, insulin sensitivity, incretin response, gut microbiota and food behavior in healthy subjects.

Conditions

• Healthy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Sucralose	Consumption of capsules containing either 200 mg sucralose (equivalent to diet soda 3 cans) per day for four weeks
DIETARY_SUPPLEMENT	Placebo	Consumption of empty capsule everyday for 4 weeks

Timeline

• Start date: 2016-01-01
• Primary completion: 2017-04-01
• Completion: 2017-04-01
• First posted: 2016-01-08
• Last updated: 2017-04-27

Locations

1 site across 1 country: Thailand