Trials / Completed
CompletedNCT02648958
Effect of Dexmedetomidine on Ischemia-Reperfusion Injury in Lower Extremity Operations
Effect of Dexmedetomidine on Ischemia-Reperfusion Injury in Unilateral Total Knee Replacement - a Randomized, Controlled Trial
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 68 (actual)
- Sponsor
- Yonsei University · Academic / Other
- Sex
- All
- Age
- 20 Years – 80 Years
- Healthy volunteers
- Not accepted
Summary
Ischemia reperfusion injury causes the release of free oxygen radicals. The selective alpha2-receptor agonist, dexmedetomidine, has an inhibitory effect on inflammatory responses during ischemic injury. The aim of this study is to evaluate the effect of dexmedetomidine on inflammatory responses during ischemia-reperfusion injury in skeletal muscle.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Dexmedetomidine | The dexmedetomidine group received the dexmedetomidine infusion at a rate of 0.4mg/kg/h after a loading dose of 0.5mg/kg for 10 minutes. |
| DRUG | normal saline | The control group received the normal saline infusion |
Timeline
- Start date
- 2016-01-01
- Primary completion
- 2017-07-31
- Completion
- 2017-07-31
- First posted
- 2016-01-07
- Last updated
- 2018-06-13
Locations
1 site across 1 country: South Korea
Source: ClinicalTrials.gov record NCT02648958. Inclusion in this directory is not an endorsement.