NCT02643992

Per-procedural Concentration of Direct Oral Anticoagulants

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 270 (actual)
• Sponsor: Fondation Ophtalmologique Adolphe de Rothschild · Network
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Background: Peri-procedural management of direct oral anticoagulants (DOAC) is challenging. The optimal duration of pre-procedural discontinuation that guarantees a minimal DOAC concentration (\[DOAC\]) at surgery is unknown. The usual 48-hour discontinuation might not be sufficient for all patients. Objectives: To investigate the factors associated with per-procedural \[DOAC\]. To test the hypothesis that a 48-hour DOAC discontinuation is not sufficient to ensure a minimal perprocedural \[DOAC\], defined as \[DOAC\] \< 30 ng/mL. Methods: Patients treated with DOAC, and requiring any invasive procedure will be included in this multicentre, prospective, observational study. \[DOAC\], will be measured during invasive procedure.

Conditions

• Per-procedural Concentrations of Oral Anticoagulants

Interventions

Type	Name	Description
OTHER	DOAC concentration measurement

Timeline

• Start date: 2013-06-01
• Primary completion: 2016-01-01
• Completion: 2016-01-01
• First posted: 2015-12-31
• Last updated: 2017-02-06

Locations

1 site across 1 country: France