Trials / Completed
CompletedNCT02637219
Innate Immune Response in COPD
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 30 (actual)
- Sponsor
- VA Puget Sound Health Care System · Federal
- Sex
- Male
- Age
- 50 Years – 89 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of this study is to determine whether the response of the immune system to bacterial components differs between patients with severe COPD compared to those with less severe COPD.
Detailed description
The airways of COPD patients are often colonized with bacteria leading to increased airway inflammation. This study sought to determine whether systemic cytokine responses to microbial pathogen-associated molecular patterns (PAMPs) are increased among subjects with severe COPD. In an observational cross-sectional study of COPD subjects, PAMP-induced cytokine responses were measured in whole blood ex vivo. We used PAMPs derived from microbial products recognized by TLR 1, 2, 4, 5, 6, 7, and 8. Patterns of cytokine response to PAMPs were assessed using hierarchical clustering. One-sided t-tests were used to compare PAMP-induced cytokine levels in blood from patients with and without severe COPD, and for subjects with and without chronic bronchitis.
Conditions
- Pulmonary Disease, Chronic Obstructive
- Immunity, Innate
- Inflammation
- Bronchitis, Chronic
- Toll-Like Receptors
Timeline
- Start date
- 2006-03-01
- Primary completion
- 2008-01-01
- Completion
- 2008-01-01
- First posted
- 2015-12-22
- Last updated
- 2015-12-22
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT02637219. Inclusion in this directory is not an endorsement.