NCT02631421

Dysregulation of Lipid Metabolism and Right Ventricular Function in PAH

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 15 (actual)
• Sponsor: Vanderbilt University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Right ventricular (RV) failure is the predominant cause of death in pulmonary arterial hypertension (PAH). No RV-specific therapies are available, in part because the underlying mechanisms of RV dysfunction are poorly understood. Given the heart's preference for fatty acids (FA) as an energy source, a deeper understanding of FA metabolism may shed light on RV adaptation to elevated afterload in PAH. The purpose of this study is to test the hypothesis that defects in fatty acid metabolism are common in PAH and contribute to RV failure. The investigators will measure peripheral and transcardiac lipid and glucose metabolites in PAH patients in comparison with patients with pulmonary venous hypertension and no evidence of pulmonary hypertension. The investigators will also correlate metabolites with concurrent measurement of right ventricular function.

Conditions

• Pulmonary Arterial Hypertension

Interventions

Type	Name	Description
PROCEDURE	Blood Sampling
OTHER	Cardiac MRI

Timeline

• Start date: 2015-01-01
• Primary completion: 2019-06-01
• Completion: 2019-06-01
• First posted: 2015-12-16
• Last updated: 2019-07-16

Locations

1 site across 1 country: United States