NCT02628249

Rate-limiting Amino Acids in Endurance-trained Athlete

Application of Indicator Amino Acid Oxidation Method to Investigate the Rate-limiting Amino Acids in Endurance Trained Athlete

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 5 (actual)
• Sponsor: University of Toronto · Academic / Other
• Sex: Male
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

Protein requirements in individuals who participate in endurance-based exercise training have been suggested to be greater than the current recommended dietary allowance (RDA). The biological value of protein depends on the amino acid composition. As liebig's law of the minimum, the protein synthesis is limited due to the lack of single rate limiting amino acid. In this case, the first rate limiting amino acid determines protein intakes to maximize the protein synthesis. Adding a small amount of rate-limiting amino acid to the diet improves the biological value of its protein diet. The indicator amino acid oxidation (IAAO) method has clarified the individual amino acid requirement in children, normal healthy adult and clinical populations. however, the IAAO method has never been utilized for determining the first rate limiting amino acid. Therefore, the purpose of this study is to address of IAAO method to be applied for determining the rate-limiting amino acid in endurance athlete.

Conditions

• Increased Metabolic Requirement
• Healthy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Base protein	0.8 g/kg/d of protein provided as crystalline amino acid modeled after egg protein
DIETARY_SUPPLEMENT	Sufficient protein	1.75 g/kg/d protein provided as crystalline amino acid modeled after egg protein.
DIETARY_SUPPLEMENT	Branched chain amino acids	Branched chain amino acids modeled after egg protein.
DIETARY_SUPPLEMENT	Essential amino acids	Essential amino acids modeled after egg protein.
DIETARY_SUPPLEMENT	Non essential amino acids	Non essential amino acids modeled after egg protein.

Timeline

• Start date: 2015-09-01
• Primary completion: 2017-06-01
• Completion: 2017-12-01
• First posted: 2015-12-11
• Last updated: 2019-04-01