NCT02627209

The Serum Angiotensin Converting Enzyme and Lysozyme Levels in Patients Non-infectious and Infectious Uveitis

Non-infectious and Infectious Uveitis Diagnosis

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 280 (estimated)
• Sponsor: Ozlem Sahin · Academic / Other
• Sex: All
• Age: 9 Years – 86 Years
• Healthy volunteers: Not accepted

Summary

This study evaluates the significance of differences in serum angiotensin converting enzyme and lysozyme levels of patients with ocular involvement of other autoimmune inflammatory and infectious diseases.

Detailed description

Increased serum levels of angiotensin converting enzyme and lysozyme are considered as inflammatory markers for diagnosis of sarcoidosis which is an autoimmune inflammatory disease. Sarcoidosis, ankylosing spondylitis and Behcet's disease are the most common autoimmune inflammatory diseases involving the eye. Elevated serum angiotensin converting enzyme levels have also been reported in tuberculosis. Syphilis and tuberculosis are the most common infectious diseases involving the eye.

Conditions

• Sarcoidosis
• Tuberculosis

Interventions

Type	Name	Description
OTHER	spectrophotometric assay	measurement of enzyme activity in the serum
OTHER	radial immunodiffusion	measurement of the precipitated ring diameters showing enzyme activity in the serum

Timeline

• Start date: 2014-06-01
• Primary completion: 2016-02-01
• Completion: 2017-01-01
• First posted: 2015-12-10
• Last updated: 2015-12-10

Locations

1 site across 1 country: Turkey (Türkiye)