NCT02624882

Impact of Antibiotic Treatment of Group A Streptococcal Blistering Distal Dactylitis in Children

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 177 (actual)
• Sponsor: Camille JUNG · Academic / Other
• Sex: All
• Age: 1 Day – 18 Years
• Healthy volunteers: Not accepted

Summary

Single-center prospective study to assess the clinical course of group A streptococcal blistering distal dactylitis in children after antibiotic treatment.

Detailed description

Blistering distal dactylitis are very common in children. About 60% are caused by Staphylococcus aureus and some are caused by Group A Streptococcus (GAS) or Streptococcus pyogenes. While these forms have been known for fifty years, few publications are interested in it. Some studies have confirmed that a single antibiotic treatment against the SGA allows the healing of these dactylitis but few surgical teams have adopted this strategy. As all streptococcal infections, they face the risk of acute complications (septicemia, streptococcal toxic shock, etc.) or late (post-streptococcal glomerulonephritis, acute rheumatic fever, etc.). The involvement of the SGA in these dactylitis is easy to demonstrate through the use of rapid GAS test already widely used in other GAS infections (tonsillitis, scarlet fever, streptococcal perianal infections). This study aims to assess the clinical course of positive GAS test blistering distal dactylitis in children after antibiotic treatment.

Conditions

• Blistering Distal Dactylitis

Interventions

Type	Name	Description
PROCEDURE	Positive rapid GAS test	If TDR positive, the child will be treated with antibiotics alone: * Amoxicillin 50mg / kg / day in 2 divided doses for 10 days (maximum dose 3 g / day in 2 divided doses) Or if allergic to penicillins and in the absence of cross-known allergy to cephalosporins * Cefpodoxime 8mg / kg / day in 2 divided doses for 10 days (maximum dose 400mg / day in 2 divided doses) J10 A control visit will review all the children included in the study. If the surgeon deems it necessary, the patient will be reviewed in consultation up to three months.
PROCEDURE	Negative rapid GAS test	Usual care

Timeline

• Start date: 2015-11-01
• Primary completion: 2018-01-01
• Completion: 2018-03-01
• First posted: 2015-12-09
• Last updated: 2018-08-02

Locations

1 site across 1 country: France