NCT02624297

Chemoreflex Control of Sympathetic Activity in Patients With Coronary Artery Disease

Effect of Exercise Training on Chemoreflex Control of Sympathetic Activity in Patients With Coronary Artery Disease and Obstructive Sleep Apnea

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: University of Sao Paulo General Hospital · Academic / Other
• Sex: All
• Age: 35 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The investigators hypothesize that chemoreflex response of muscle sympathetic nerve activity (MSNA) during hypoxia and hypercapnia will be increased in coronary artery disease (CAD) patients and that the presence of obstructive sleep apnea (OSA) will potentiate these responses. And, that the exercise training would decrease the chemoreflex response of MSNA in these patients.

Detailed description

Forty patients with coronary artery disease, with (n=20) and without (n=20) obstructive sleep apnea will be studied. A healthy control, age-paired group (n=10) will be also evaluated. The patients will be submitted to a polysomnography and randomized for clinical follow-up or exercise training for four months. It will evaluated the autonomic function, chemoreflex control of sympathetic activity during hypoxic and hypercapnic maneuvers, endothelial function and inflammatory markers.

Conditions

• Coronary Artery Disease (CAD)
• Obstructive Sleep Apnea (OSA)

Interventions

Type	Name	Description
OTHER	Aerobic exercise training	The patients will be submitted to four months of aerobic exercise training, three time a week.

Timeline

• Start date: 2014-01-01
• Primary completion: 2017-12-01
• Completion: 2020-01-01
• First posted: 2015-12-08
• Last updated: 2017-05-16

Locations

1 site across 1 country: Brazil