NCT02622490

Acute Effects of Different Macronutrient Compositions and Meal Distributions of the Food

Diet-induced Thermogenesis 2

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 28 (actual)
• Sponsor: University Hospital, Linkoeping · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

About thirty participants, of varying degrees of obesity or being non-obese, without serious concomitant diseases consume either a high- or a low- carbohydrate beverage. The beverage is also consumed either as one single drink or as 5 small portions in the morning and are tested for effects on major cardiovascular risk markers and on metabolic rate for three hours on each occasion.

Detailed description

Thirty participants come to the metabolic ward at about 8 o´clock in the fasting state and stay until lunch on four occasions each. The participants are randomized to the order of the test meals. The meals have a total caloric content of 750 kcal and have either 50% of energy from carbohydrates (low fat) or 20% of energy from carbohydrates (low carb.). The meals are consumed on one occasion in the morning or divided in 5 portions (150 kcal each) for every 30 minutes, i.e. total combinations of meal composition and of meal distribution is 4. Effects of the food on p-glucose, s-insulin, blood-lipids, hormones and on metabolic rate is measured by blood tests or by indirect calorimetry (for metabolic rate). Sense of satiety is measured by visual analogue scales.

Conditions

• Metabolic Rate
• Plasma Glucose
• Serum Insulin
• Serum Triglycerides
• Sense of Satiety

Interventions

Type	Name	Description
OTHER	two test meals with two different macronutrient compositions	Either a high or a low carb meal either as one large or as 5 small meals. ie a crossover trial with one arm

Timeline

• Start date: 2015-09-01
• Primary completion: 2020-05-01
• Completion: 2020-05-01
• First posted: 2015-12-04
• Last updated: 2019-04-24

Locations

1 site across 1 country: Sweden