NCT02621866

A Trial of Daily Ultraviolet Therapy to Reduce Cardiovascular Risk Factors

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 13 (actual)
• Sponsor: University of Edinburgh · Academic / Other
• Sex: All
• Age: 16 Years
• Healthy volunteers: Not accepted

Summary

The investigators have shown that a single dose of ultraviolet irradiation (as found in sunlight) will lower blood pressure for around one hour. They are now testing whether daily UVA for two weeks will produce a sustained fall in BP in patients with high blood pressure. They will also measure the effect of daily UVA on other cardiovascular risk factors.

Detailed description

Epidemiological studies suggest that sunlight reduces all cause mortality, and particularly cardiovascular mortality. The investigators have previously shown vasodilatation and a transient fall in blood pressure following irradiation of human volunteers with 2 standard erythemal doses of UVA radiation. This was independent of vitamin D and temperature rise and correlated with a nitric oxide synthase independent mobilisation of NO stores from the skin to the systemic circulation. In this randomised, sham-controlled, cross-over double blind study, they will measure whether twice daily UVA administration can produce a sustained fall in BP and other cardiovascular risk factors in a cohort of pre-hypertensive patients.

Conditions

• Hypertension

Interventions

Type	Name	Description
DEVICE	Ultraviolet A radiation	Twice daily with 10 Joules/cm2. Half body (one side) with Waldmann 100L phototherapy lamp fitted with UVA bulbs (main emission 320-410nm)
DEVICE	Sham irradiation	As active, but lamps to be shielded with Amber 81 museum film which prevents transmission of \<500nm, but permits visible light to pass.

Timeline

• Start date: 2017-05-02
• Primary completion: 2019-08-31
• Completion: 2019-08-31
• First posted: 2015-12-04
• Last updated: 2024-05-13

Locations

1 site across 1 country: United Kingdom