NCT02620813

De Novo Lipogenesis of Sebaceous Glands in Acne

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 32 (actual)
• Sponsor: University of California, Davis · Academic / Other
• Sex: All
• Age: 15 Years – 45 Years
• Healthy volunteers: Accepted

Summary

There are two purposes of this study: 1. First, the investigators want to see what the differences are in de novo sebaceous lipid production of people with and without acne. 2. Secondly, the investigators want to know what happens to sebaceous gland de novo lipid production before and after treatment with topical tretinoin and oral isotretinoin.

Detailed description

The primary objective of this study is to understand how de novo lipid production of sebaceous glands are altered in acne and with acne directed therapy. Hypothesis 1: The overall de novo lipogenesis will be increased in those with acne Hypothesis 2: Treatment with topical tretinoin and systemic isotretinoin will reduce de novo lipogenesis.

Conditions

• Acne Vulgaris

Interventions

Type	Name	Description
DRUG	Tretinoin	Subjects will apply 0.5% tretinoin cream nightly to their face for a total of 12 weeks.
DRUG	Isotretinoin	Subjects will take isotretinoin as prescribed by their dermatologist.

Timeline

• Start date: 2015-10-01
• Primary completion: 2017-10-12
• Completion: 2017-10-12
• First posted: 2015-12-03
• Last updated: 2021-08-05

Locations

2 sites across 1 country: United States