NCT02619786

Therapy of Ventilator-associated Tracheobronchitis Caused by Gram Negative Bacteria With Nebulized Colistin

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 62 (estimated)
• Sponsor: Mahidol University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether inhaled colistin is effective in the treatment of ventilator associated tracheobronchitis due to gram negative organism susceptible to colistin.

Detailed description

Patients diagnosed ventilator-associated tracheobronchitis due to gram negative organism are included to the study.The patients will be received colistin inhalation 75 mg every 12 hours at least 5 days. The primary objective is to evaluate clinical outcome of inhaled colistin. The secondary objectives are microbiological clearance and toxicity of inhaled colistin. The sample size was estimated to 62 patients.

Conditions

• Bronchitis

Interventions

Type	Name	Description
DRUG	Inhaled colistin	75 mg of colistin activity, inhaled per dose, every 12 hours

Timeline

• Start date: 2015-12-01
• Primary completion: 2017-05-01
• Completion: 2017-12-01
• First posted: 2015-12-02
• Last updated: 2015-12-02