NCT02619656

A Trial of Supplemental CO2 Versus Room Air in Percutaneous Endoscopic Gastrostomy

Insufflation With Carbon Dioxide Reduces Pneumoperitoneum After Percutaneous Endoscopic Gastrostomy (PEG): A Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 35 (actual)
• Sponsor: University of Utah · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The investigators hypothesize that using carbon dioxide for PEG placement versus using room air will decrease post-procedure pneumoperitoneum as well as improve post-procedure bloating/pain, and waist circumference.

Detailed description

Background and study aims: Pneumoperitoneum following PEG placement has been reported in up to 60% of cases, and while usually benign and self-limited, it can lead to evaluation for suspected perforation. This study was designed to determine whether using CO2 compared to ambient air for insufflation during PEG reduces post-procedure pneumoperitoneum. Patients and Methods: Prospective, double blind, randomized trial of 35 consecutive patients undergoing PEG at a single academic medical center. Patients were randomized to insufflation with CO2 or ambient air. Primary outcome was pneumoperitoneum determined by left-lateral decubitus abdominal x-rays 30 min after PEG placement. Secondary endpoints included abdominal distention, pain, and bloating.

Conditions

• Pneumoperitoneum

Interventions

Type	Name	Description
PROCEDURE	CO2 insufflation	Patients were randomized to insufflation with CO2.
PROCEDURE	Ambient air insufflation	Patients were randomized to insufflation with ambient air.

Timeline

• Start date: 2012-04-01
• Primary completion: 2015-06-01
• Completion: 2015-06-01
• First posted: 2015-12-02
• Last updated: 2015-12-02

Locations

1 site across 1 country: United States