NCT02619539

Shock Index To DEtect Low Plasma Fibrinogen In Trauma (SIDE)

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 280 (actual)
• Sponsor: Masaryk Hospital Krajská zdravotní a.s. · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Shock-index is potentially an easy tool to estimate the risk of hypofibrinogenemia without the need to perform other potentially time consuming investigations.

Detailed description

Hypofibrinogenemia is common in severe trauma and below the threshold of 2.3 g/l is associated with increased mortality. Although guidelines for management of the trauma induced coagulopathy does not recommend any specific timing of fibrinogen substitution, several papers suggest that early substitution might be associated with improved outcome. Laboratory measurement of plasma fibrinogen level, thromboelastometry and/or its estimation based on base excess, hemoglobin level, Injury Severity Score or combinations require diagnostic procedures that are associated with with a certain time delay and prolongs the time to fibrinogen substitution.

Conditions

• Trauma, Multiple

Interventions

Type	Name	Description
PROCEDURE	plasma fibrinogen measurement	plasma fibrinogen measurement

Timeline

• Start date: 2016-01-01
• Primary completion: 2017-02-28
• Completion: 2017-02-28
• First posted: 2015-12-02
• Last updated: 2017-03-24

Locations

2 sites across 1 country: Czechia