NCT02619071

ChEmo-Genomics Based Treatment of Acute Myeloid Leukemia

ChEmo-Genomics Based Treatment of Acute Myeloid Leukemia- CeGAL-IPC 2014-012

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 87 (estimated)
• Sponsor: Institut Paoli-Calmettes · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Adult acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy associated with poor prognosis, especially after relapse. High-throughput genomic studies have highlighted the importance of molecular alteration in the pathophysiology, clinical evolution and treatment response of AML. In addition, identification of specific gene mutation can be targeted by specific inhibitors, opening the way to personalized treatments. However, only a limited number of gene mutations are druggable or actionable, highlighting the need for additional information to guide treatment choices. Among them, new Drug Screening Tests (DST) allow for the screening of library of hundreds of drugs to ex-vivo patient-derived AML cells. Combination of genomic and pharmacologic approaches might therefore improve prediction of drug effects. There is an urgent need to bring these approaches into the clinic but feasibility trials are necessary before incorporating them into treatments strategies.The proposed study is a prospective multicentre feasibility study of a combined "chemo-genomic" approach in patients with advanced AML.

Conditions

• Leukemia, Myeloid, Acute

Interventions

Type	Name	Description
PROCEDURE	Tumor sampling	Bone marrow aspirate, blood sampling
BIOLOGICAL	Constiutional DNA sampling	Buccal swab or Hair follicles

Timeline

• Start date: 2015-08-01
• Primary completion: 2017-08-01
• Completion: 2017-08-01
• First posted: 2015-12-02
• Last updated: 2016-06-28

Locations

1 site across 1 country: France