NCT02619019

Effect of Spinal Dexamethasone During Transuretheral Prostatectomy

Intrathecal Dexamethasone in Patients Undergoing Transuretheral Prostatectomy.

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 90 (actual)
• Sponsor: Assiut University · Academic / Other
• Sex: Male
• Age: 50 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Dexamethasone, a high-potency, long-acting glucocorticoid, when added to bupivacaine, it extended the duration of analgesia. We aim to study the effectiveness of spinal dexamethasone in Transuretheral prostatectomy.

Detailed description

Spinal anesthesia for endoscopic urology surgery like transurethral resection of the prostate is a well-established technique. Opioids are extensively used as an adjunct to local anesthetics in neuraxial blockade to enhance the duration of postoperative analgesia. However, worrisome adverse effects like pruritus, urinary retention, postoperative vomiting and respiratory depression limit its use. The aim of this study was to investigate the effectiveness of Intrathecal dexamethasone as adjunct to local anesthetics.

Conditions

• Postspinal Shivering

Interventions

Type	Name	Description
DRUG	Dexamethasone	Patients will receive 8 mg of hyperbaric bupivacaine 0.5%, plus 8 mg of dexamethasone intrathecally
DRUG	Pethidine	Patients will receive 8 mg of hyperbaric bupivacaine 0.5%, plus 0.2 mg/kg of pethidine intrathecally
DRUG	Normal saline	Patients will receive 8 mg of hyperbaric bupivacaine 0.5%, plus 2 ml normal saline intrathecally

Timeline

• Start date: 2015-11-01
• Primary completion: 2016-06-01
• Completion: 2016-06-01
• First posted: 2015-12-02
• Last updated: 2016-09-15

Locations

1 site across 1 country: Egypt